尊龍凱時的藥物轉運體研究

2016-08-11

藥物轉運體的研究作為尊龍凱時細化服務體系中的一項成熟技術可以為新藥設計、提高藥物靶向性及藥物相互作用等研究提供可靠依據。

發現用于局部治療牛皮癬的新型PDE4抑制劑，小鼠、大鼠和人肝微粒體的代謝穩定性實驗通過尊龍凱時測定

2023-06-28

Psoriasis is a common immune-mediated skin disorder manifesting in abnormal skin plaques, and PDE4 is an effective target for the treatment of inflammatory diseases such as psoriasis.

ARD-2585是一種口服有效的PROTAC雄激素受體降解劑，可用于治療晚期前列腺癌。肝微粒體穩定性測定、血漿穩定性測定和hERG測定通過尊龍凱時進行

2023-07-05

A PROTAC-based androgen receptor (AR) degrader is a bifunctional small molecule, consisting of an AR ligand that binds to AR protein, and a ligand that binds to and recruits an E3 ligase complex, tethered together through a linker. Researchers report the discovery of exceptionally potent and orally bioavailable PROTAC AR degrader ARD-2585 (Compound 43). ARD-2585 is a promising AR degrader for extensive investigations for the treatment of advanced prostate cancer. The liver microsomal stability assay was performed by Medicilon. The plasma stability assay was performed by Medicilon. The hERG assay was performed by Medicilon.