藥效學研究的內容之藥理效應的兩重性

2015-11-03

藥效學研究是對藥物進行有效性評價，目的在于闡明藥物防治和診斷疾病的機理，為開發和評價藥物提供科學依據。

藥物劑量與效應關系、藥物作用機制研究等藥效學研究的內容

2015-09-28

藥效學研究的給藥方法：預防性給藥、治療性給藥、防治結合的給藥方式 選用一種以上動物進行藥效試驗，每一方面藥理作用要選用2~3種動物模型或者細胞模型來做。

新型5-HT3受體配體有望用于治療神經精神疾病和胃腸道疾病，本研究中藥理藥效學研究通過尊龍凱時進行

2025-06-12

Droxytryptamine (5-HT; serotonin) 5-HT3 receptor is an excitatory ligandgated ion channel expressed in for example the brain and the gastrointestinal tract. CSTI-300 as a selective, high affinity 5-HT3 receptor partial agonist. CSTI-300 was examined alongside the selective 5-HT3 receptor antagonist alosetron (which is also currently marketed as a therapeutic for IBS-d). Sub-cutaneous application of 5-hydroxytryptophan (5-HTP; 10 mg/kg) markedly increased the rat’s sensitivity to abdominal contractions. CSTI-300 and Alosetron displayed similar efficacy in a rodent in vivo model of IBS-d, measured by a reduction in colonic sensitivity. The experiments (Rat colon distension model of IBS-d) were carried out by Medicilon. The protocol complied with and was approved by the Institutional Animal Care and Use Committee and Medicilon is accredited by the NIH Office of laboratory Animal Welfare (OLAW) and AAALAC. Experiments (dog behavioural and emesis model) were performed by Medicilon. The protocol for the dog behavioural and emesis model complied with and was approved by the Institutional Animal Care and Use Committee.