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搜索結果包含 inhibition 的內容

Jul 06,2023
BRD4抑制劑可用于治療腎纖維化,ZLD2218可有效抑制BRD4活性,對ZLD2218的PK研究通過尊龍凱時進行
Uncovering new therapeutics for kidney fibrosis hold promise for chronic kidney disease (CKD). BRD4 inhibition ameliorated kidney injury and fibrosis. ZLD2218 exhibited the potent inhibitory activity
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Jul 06,2023
開發具有口服活性的高度選擇性卵泡刺激激素受體激動劑,且進行臨床前研究。其中對大鼠和狗的毒理學評估通過尊龍凱時進行
TOP5300 is an orally active follicle stimulating hormone receptor allosteric agonist that provides a preferred treatment for over 16 million infertile women of reproductive age in low complexity metho
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Jul 06,2023
PARP1/2抑制劑有治療腫瘤的潛力,PARP1/2抑制實驗通過尊龍凱時進行
Poly ADP-ribose polymerases (PARPs) are a family of enzymes related to DNA damage repair process.?Inhibition of PARP1/2 accelerates the damage of injured DNA, which is synthetically lethal to DNA
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Jul 05,2023
研究人員設計合成STAT3和HDAC雙通路抑制劑用于治療實體腫瘤,PK實驗通過尊龍凱時進行
The inhibition of HDACs will lead to compensated activation of a notorious cancer-related drug target, STAT3, in breast cancer through a cascade, which probably limits the anti-proliferation effect of
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Jul 05,2023
端錨聚合酶1/2影響WNT/β-連環蛋白和Hippo信號通路,這些信號通路涉及包括腫瘤在內的多種疾病
Tankyrase 1 and 2 (TNKS1/2) impact the WNT/β-catenin and Hippo signaling pathways that are involved in numerous human disease conditions including cancer. OM-153 shows picomolar IC50 inhibition in a c
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Jun 28,2023
設計合成一種新型選擇性的口服有效蘇氨酸酪氨酸激酶 (TTK) 抑制劑,PK研究均通過尊龍凱時進行
TTK inhibition is an attractive wide-spectrum strategy for cancer therapy. Researchers designed and synthesized a series of pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable TTK inhibitors. All the pharmacokinetic studies were carrie
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Jun 28,2023
H11-HLE是一種工具分子,可用于研究Fc在介導免疫檢查點治療中的作用,具有抗腫瘤功效
Immune checkpoint inhibition therapies have been used for multiple cancer research. H11-HLE is a tool molecule that allows the interrogation of the contribution of Fc in mediating immune checkpoint therapy. Half-life extended H11 (H11-HLE) induces potent
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