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信號轉導和轉錄激活因子(signal transducer and activator of transcription, STAT)是一大類具有細胞質內信號轉導和細胞核內轉錄激活雙重作用的蛋白，廣泛存在于哺乳動物細胞中，介導多種細胞內信號通路。

The signal transducer and activator of transcription (STAT) is a family of intracellular cytoplasmic transcription factors involved in many biological functions in mammalian signal transduction.

STAT3是一種在多種組織中表達的信號分子。STAT3參與細胞增殖、分化、凋亡和炎癥反應等多種生物學過程。然而，STAT3在大多數人類癌癥中變得過度激活，通常與不良的臨床預后有關。

Among them STAT3 is involved in cell proliferation,differentiation,apoptosis and inflammatory responses, and also STAT3-related signaling pathways are a barren over-activated in many types of cancer and are strongly associated with poor patient prognosis.

腫瘤微環境（TME）中腫瘤細胞內STAT3過度激活會介導一系列細胞外信號，增強腫瘤微環境的免疫炎癥反應，驅動腫瘤細胞增殖、侵襲和轉移，同時強烈抗腫瘤免疫反應并創造免疫抑制微環境。

Excessive activation of STAT3 within tumor cells and other cells in the tumor microenvironment (TME) mediates a series of extracellular signals that enhances the immune inflammatory response in a TME, driving tumor cell proliferation, invasion, and metastasis, while strongly suppressing the anti-tumor immune response and creating an immunosuppressive microenvironment.

研究表明，持續激活的STAT3對于多種癌癥是必不可少的，比如乳腺癌和結直腸癌，這使得STAT3成為理想的藥物靶點。

Studies have indicated that persistently activated STAT3 is indispensable for various cancers including breast cancer and coleractal cancer ,which makes it an ideal drug target.

尊龍凱時可提供STAT3藥物發現、CMC研究（API+制劑）、藥效研究、PK研究、安全性評價等一站式研發服務。

Medicilon provides STAT3 drug discovery, CMC Research (API + formulation), pharmacodynamics research, PK study, safety evaluation and other services.

STAT3藥物靶點研發服務

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