zapERtrap opens the door to previously unapproachable questions concerning how proteins are processed, trafficked, and secreted in space and time in complex cellular environments. zapERtrap relies on a small-molecule protein dimerizer zapalog, which consists of the antibiotic trimethoprim tethered to a synthetic ligand of FK506-binding protein through a photocleavable linker. Synthesis of zapalog was performed by Medicilon.

Reference:

Ashley M Bourke, et al. zapERtrap: A light-regulated ER release system reveals unexpected neuronal trafficking pathways. J Cell Biol. 2021 Sep 6;220(9):e202103186. doi: 10.1083/jcb.202103186.

zapERtrap 光調節內質網定制合成 chemistry customized synthesis

苯并咪唑衍生物XY123是一種口服有效的選擇性RORγ反向激動劑。在本研究中，所有肝微粒體測定均通過尊龍凱時進行返回端錨聚合酶1/2影響WNT/β-連環蛋白和Hippo信號通路，這些信號通路涉及包括腫瘤在內的多種疾病

2023-05-29

In summary, the efficient and scalable intramolecular cyclopropanation of active methylene compounds via electrocatalysis with an organic catalyst can solve challenges from the transition metal catalyzed alkene cyclopropanation of functionalized compounds, such as α-diazocarbonyl compounds and increase operational safety.

研究人員使用RZ-2994來表征抑制SHMT1/2在T細胞急性淋巴細胞白血病 (T-ALL) 中的作用，RZ-2994通過尊龍凱時定制合成

2023-07-05

?Despite progress in the treatment of T-cell acute lymphoblastic leukemia (T-ALL) has limited treatment options, particularly in the setting of relapsed/refractory disease. Researchers used SHMT1/2 inhibitor RZ-2994 to characterize the effect of inhibiting SHMT1/2 in T-ALL. Loss of both SHMT1/2 is necessary for impaired growth and cell cycle arrest, with suppression of SHMT1/2 inhibiting leukemia progression. RZ-2994 also decreases leukemia burden in vivo. RZ-2994 was obtained from Medicilon. Medicilon offers a full range of chemical services covering all phases of your project. Customers can work with us either through FFS or FTE.

代碼

688202

川沙總部

地址: 上海市浦東新區川大路585號

郵編: 201299