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Phosphodiesterase-1 (PDE1) is a promising drug target closely related to central and peripheral diseases. Compound 2j with the IC50 of 21 nM against PDE1B, shows good metabolic stability in the rat liver microsomes. Stability test in the rat liver microsomes were performed by Medicilon.
Reference:
Bei Zhang, et al. Design, synthesis and biological evaluation of novel pyrazolopyrimidone derivatives as potent PDE1 inhibitors. Bioorg Chem. 2021 Sep;114:105104. doi: 10.1016/j.bioorg.2021.105104.
Time: March 4, 2023 09:00-10:00(ET)
Time: March 4, 2023 22:00-23:00 (Beijing)
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