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Biofouling poses one of the most serious problems to marine industry and aquaculture development. Five structurally similar compounds were isolated from the crude extract of a marine Streptomyces strain. Antifouling activities of these compounds and four other structurally-related compounds isolated from another marine Streptomyces species were compared to generate structure–activity relationship data. Based on structure–activity relationship analysis, another compound with a simplified structure but excellent antifouling activities was synthesized. The optimized compound was synthesized by Medicilon.

Reference:

Ying Xu, et al. Potent antifouling compounds produced by marine Streptomyces. Bioresour Technol. 2010 Feb;101(4):1331-6. doi: 10.1016/j.biortech.2009.09.046.